Buy 4-Aco-DMT

We offer industrial‑grade 4‑Aco‑DMT (4‑acetoxy‑N,N‑dimethyltryptamine) powder in bulk quantities to qualified laboratories and research institutions. Our 4‑Aco‑DMT is purity‑verified and intended solely for analytical, forensic, and pharmacological research applications.

4‑Aco‑DMT, also known as psilacetin or O‑acetylpsilocin, is a synthetic tryptamine that functions as a prodrug to psilocin and is widely used in neurochemical studies and structure-activity analysis. It was first synthesized in the early 1960s by Albert Hofmann and Franz Troxler as an easier-to-manufacture analog of psilocybin.

Description and Research Use

4‑Aco‑DMT is widely used in advanced serotonergic receptor research and psychedelic pharmacology, particularly as a prodrug to psilocin. Early pharmacological studies show its action on the 5‑HT₂A receptor, similar to psilocybin and psilocin. Animal studies confirm head-twitch responses in rodents—an indicator of hallucinogenic receptor activation. 

Due to its prodrug nature, 4‑Aco‑DMT is metabolized to psilocin in vitro and in vivo, making it a cleaner alternative to psilocybin for controlled receptor studies. Custom research applications include controlled dosage models, receptor binding dynamics, toxicology benchmarking, and analytical reference calibration.

Applications

• Standard reference for mass spectrometry and HPLC

• Serotonin receptor agonist assays (5‑HT₂A, 5‑HT₁A)

• Psychoactive compound structure‑activity relationship studies

• Controlled synthetic or animal-based pharmacology

• Forensic and analytical labs requiring verified tryptamine standards

Why Choose CityChems?

• Full traceability with Certificates of Analysis (COA)

• ISO-level quality control and lab-verified purity

• Discreet, trackable shipping worldwide

• Bulk pricing and flexible volume supply

• Compliance-focused customer onboarding and documentation